Both teams had a player sent off in the first half, with Robert Sanchez receiving a red card just five minutes into the game after bringing down Bryan Mbeumo. This was Chelsea's earliest red card in the Premier League.
Manchester United's Casemiro scored a goal and was sent off in the first half, a rare feat in the Premier League. This was the first time a Manchester United player had achieved this since Emmanuel Adebayor in 2012.
The match started with heavy rain, and Chelsea's prospects were already challenging after Sanchez's red card. Despite a double change by Enzo Maresca, Manchester United's pressure continued, and they took the lead after 14 minutes with a goal from Bruno Fernandes. Fernandes scored his 100th goal for the club.
Maresca made further changes, bringing on Andrey Santos for Cole Palmer, but Manchester United's momentum continued. Chelsea struggled to deal with a cross from a short corner routine, and Luke Shaw kept the ball alive for Casemiro to head it home and extend the lead.
Casemiro was sent off in the 31st minute for a second yellow card, having been booked earlier for a challenge on Enzo Fernández. Ruben Amorim made a change, bringing on Manuel Ugarte for Šeško, ahead of the second half.
The second half saw Chelsea trying to mount a comeback, but Manchester United's defense held strong. Chelsea thought they had a lifeline when Tosin Adarabioyo's flick-on led to Wesley Fofana heading the ball in, but the goal was ruled offside.
Chelsea eventually scored with 10 minutes remaining, as Trevoh Chalobah headed in a cross from Reece James. Manchester United saw out the rest of the match, securing a second win in their last three matches and ending Chelsea's undefeated season in the Premier League.
Manchester United inflicted Chelsea's first Premier League defeat of the season, and the Blues are now winless in their last three matches across all competitions.