The decision comes after a disappointing season from the team's current striker options, Rasmus Hojlund and Joshua Zirkzee. Manchester United's manager, Ruben Amorim, is looking to strengthen his team's attack this summer.
Sesko, 22, has been expected to leave RB Leipzig this summer after they failed to qualify for European football. This is their worst season since being promoted to the Bundesliga.
However, Manchester United won't be the only club bidding for Sesko. Newcastle United is also interested in signing him, and may make a bid as they prepare for a potential move for their current striker, Alexander Isak.